منابع مشابه
Puma strikes Bax
The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue, Gallenne et al. (Gallenne, C., F. Gautier, L. Oliver, E. Hervouet, B. Noël, J.A. Hickman, O. Geneste, P.-F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. J. Cell Biol. 185:279-290) provide evidence that the p53 up-regulated modulator ...
متن کاملHsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
Hsp90 is widely overexpressed in cancer cells and believed to be essential for the maintenance of malignant phenotypes. Targeting Hsp90 by small molecules has shown promise in solid and hematologic malignancies, which likely involves degradation of client oncoproteins in a cell-type-specific manner. In this study, we found that structurally unrelated Hsp90 inhibitors induce DNA damage and apopt...
متن کاملp73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.
p73, an important developmental gene, shares a high sequence homology with p53 and induces both G(1) cell cycle arrest and apoptosis. However, the molecular mechanisms through which p73 induces apoptosis are unclear. We found that p73-induced apoptosis is mediated by PUMA (p53 up-regulated modulator of apoptosis) induction, which, in turn, causes Bax mitochondrial translocation and cytochrome c...
متن کاملPUMA Promotes Bax Translocation by Both Directly Interacting with Bax and Competitive Binding to Bcl-XL during UV-induced Apoptosis
Cell apoptosis induced by UV irradiation is a highly complex process in which different molecular signaling pathways are involved. PUMA has been proposed as an important regulator in UV irradiation-induced apoptosis. However, the molecular mechanism through which PUMA regulates apoptosis, especially how PUMA activates Bax in response to UV irradiation is still controversial. In this study, base...
متن کاملTargeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma.
Despite recent therapeutic advances that have doubled the median survival time of patients with multiple myeloma, intratumor genetic heterogeneity contributes to disease progression and emergence of drug resistance. miRNAs are noncoding small RNAs that play important roles in the regulation of gene expression and have been implicated in cancer progression and drug resistance. We investigated th...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2009
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200903134